cryo storage for +4℃, -20℃, -80℃ and -196℃
infrastructure for collecting and distributing samples
molecular biology, bio-informatics
registries and standard e-CRF for clinical data collection
The Durrer Center for cardiovascular research (Durrer Center) is a national multidisciplinary collaboration of academic research institutes in the field of cardiology, genetics and biostatistics partaking in cardiovascular genetic and epidemiological studies and associated biobanks.
Durrer Center provides expertise, infrastructure and services for collecting, comparing, harmonizing and merging results from individual cardiovascular genetic studies. By combining these different cohorts and making them centrally accessible and visible it creates the possibility to deliver more effective health care strategies aimed at cardiovascular disease prevention, and at tailoring medicines and other treatment regimens to individuals, families and communities.
Since 2008, the Durrer Center has supported 32 independent research projects for samples and/or data storage. The Durrer Center has also provided research support for molecular biology and bio-informatic analyses.
Durrer Center provides a number of services for (multi-centre) research projects. These services include:
- cryo storage for +4℃, -20℃, -80℃ and -196℃
- lab facilities for receiving and distributing samples
- web based sample tracking / storage system
- virtual registry of existing collections
- website with overview of collected materials plus basic descriptive information (new)
- Logistic support:
- infrastructure for collecting and distributing samples
- equipment for transporting samples (+4℃, -20℃, -80℃ and -196℃)
- Research support:
- molecular biology: access to state of the art lab facilities including most techniques for research focused on molecular biology (e.g. robotized DNA extraction, quality/quantity check on DNA/RNA, Sanger sequencing, Next Generation Sequencing (Roche/Solexa), gene expression analyses (quantitative PCR), genotyping (e.g. Taqman), copy number variation analyses (MLPA, qPCR), whole genome DNA amplification)
- bio-informatics: expertise and hardware for doing elaborate statistical analysis on several different output formats or complex genetics analysis (e.g. GWAS)
- Legal-ethical support:
- Trial management:
- development of formats for registries and standard e-CRF for clinical data collection
The Durrer Center manages a couple of catalogues, they are listed below. By clicking on the link the catalog will open in a new window.
Durrer Center studies Catalogue:
This catalogue gives an overview of all the studies that are stored at the Durrer Center. This catalogue can be used by researchers to find interesting cohorts/samples for their study.click here for the Durrer Center study collection
Patients with primary cardiac arrhythmia syndromes (ion channelopathies) or secondary cardiac arrhythmia syndromes (cardiomyopathies) with a known mutation are included in the GENCOR catalogue. Patients with structural congenital heart defects (e.g. Tetralogy of Fallot, aortic coarctation, ventricular septal defect and atrial septal defects, aortic valvar stenosis) or Marfan syndrome are excluded from participation.
Cardiac Tissue Biobank Utrecht:
The Cardiac Tissue Biobank Utrecht combines clinical and genetic data with cardiac tissue collected by the departments of pathology and cardiology from UMC Utrecht starting from the 1980’s. Included biobank materials are cardiac tissue (e.g. biopsies, heart slices), fibroblast cell cultures, plasma, and DNA. In total, more than 500 patients with an ischemic or non-ischemic cardiomyopathy who underwent a heart transplantation or left ventricular assist device implantation are included in the Cardiac Tissue Biobank Utrecht. This study catalogue is financially supported by BBMRI-NL, a Research Infrastructure financed by the Dutch government (NWO 184.021.007)click here for Cardiac Tissue Biobank Utrecht
International DCM database:click here for the International DCM database