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The Durrer Center for cardiovascular research (Durrer Center) is a national multidisciplinary collaboration of academic research institutes in the field of cardiology, genetics and biostatistics partaking in cardiovascular genetic and epidemiological studies and associated biobanks.

Durrer Center provides expertise, infrastructure and services for collecting, comparing, harmonizing and merging results from individual cardiovascular genetic studies. By combining these different cohorts and making them centrally accessible and visible it creates the possibility to deliver more effective health care strategies aimed at cardiovascular disease prevention, and at tailoring medicines and other treatment regimens to individuals, families and communities.

Since 2008, the Durrer Center has supported 32 independent research projects for samples and/or data storage. The Durrer Center has also provided research support for molecular biology and bio-informatic analyses.

 
Durrer Center op biobanken.nl
Op biobanken.nl is afgelopen week een leuk stuk verschenen in de rubriek” biobanken uitgelicht”:
http://www.biobanken.nl/in-de-praktijk/durrer-center-hart-voor-onderzoek/
 
Prijswinnaar Beste Professionele Idee Flevoland, goed voor Euro 50.000
ICIN-NHI Durrer Center / Hospitrace – Open One Health BioBank
Onderzoekers hebben de verantwoordelijkheid om verzamelde data en biomaterialen conform geldende regelgeving op te slaan en indien wenselijk beschikbaar te stellen voor nieuw onderzoek. Open One Health BioBiank heeft als doel veterinair en humaan onderzoek hierin te faciliteren en brengt expertise op het gebied van applicatie workflow, virtuele (data) infrastructuur en fysieke (bio-materiaal) opslag samen volgens het shared service model. De BioBank zal een gecertificeerde infrastructuur inrichten en zich richten op ziekenhuizen, diagnostische centra, industrieën en innovatieve life-science start-ups om zowel klein- als grootschalig onderzoek te ondersteunen en te initiëren.
De initiatiefnemers kiezen met de Open One Health Biobank voor een geheel nieuwe benadering, waarbij de medical need centraal staat, aldus de jury. De jury is van mening dat er in Nederland een Open One Health Biobank moet komen, die zorgt voor het ontsluiten van humane en veterinaire kennis.
www.durrercenter.nl / www.quaerosystems.com

bron: www.humanimal.nu
 
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Tandemtocht levert 18.000 euro op voor onderzoek naar hartfalen
Maar liefst 80 deelnemers zijn afgelopen zondag op de tandem gestapt om geld bij elkaar te fietsen voor onderzoek naar erfelijk hartfalen. De derde editie van de tandemtocht, georganiseerd door het UMC Utrecht Hart- en vaatcentrum, heeft ruim € 18.000 opgehaald voor Vrienden UMC Utrecht.
 
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Logo_Hartstichting_fund_Eng_RGB_posPrintICIN_logo
 

Services

Durrer Center provides a number of services for (multi-centre) research projects. These services include:

  • Biobanking:
    • cryo storage for +4℃, -20℃, -80℃ and -196℃_DSC1461
    • lab facilities for receiving and distributing samples
    • web based sample tracking / storage system
    • virtual registry of existing collections
    • website with overview of collected materials plus basic descriptive information (new)

 

  • Logistic support:
    • infrastructure for collecting and distributing samples
    • equipment for transporting samples (+4℃, -20℃, -80℃ and -196℃)

 

  • Research support:sideimage-2
    • molecular biology: access to state of the art lab facilities including most techniques for research focused on molecular biology (e.g. robotized DNA extraction, quality/quantity check on DNA/RNA, Sanger sequencing, Next Generation Sequencing (Roche/Solexa), gene expression analyses (quantitative PCR), genotyping (e.g. Taqman), copy number variation analyses (MLPA, qPCR), whole genome DNA amplification)
    • bio-informatics: expertise and hardware for doing elaborate statistical analysis on several different output formats or complex genetics analysis (e.g. GWAS)

 

  • Legal-ethical support:
    • assistance in arranging documents on informed consent, material transfer and contracts._DSC1465
    • possibility to consult a qualified legal expert for questions pertaining to legal or ethical issues
    • collect documentation necessary for legal and ethical aspects of sample collection and storage

 

  • Trial management:
    • development of formats for registries and standard e-CRF for clinical data collection

Study Catalogue

The Durrer Center manages a couple of catalogues, they are listed below. By clicking on the link the catalog will open in a new window.

Durrer Center studies Catalogue:

This catalogue gives an overview of all the studies that are stored at the Durrer Center. This catalogue can be used  by researchers to find interesting cohorts/samples for their study.

click here for the Durrer Center study collection

GENCOR Catalogue:
Patients with primary cardiac arrhythmia syndromes (ion channelopathies) or secondary cardiac arrhythmia syndromes (cardiomyopathies)  with a known mutation are  included in the GENCOR catalogue. Patients with structural congenital heart defects (e.g. Tetralogy of Fallot, aortic coarctation, ventricular septal defect and atrial septal defects, aortic valvar stenosis) or Marfan syndrome are excluded from participation.

click here for the GENCOR database

Cardiac Tissue Biobank Utrecht:

The Cardiac Tissue Biobank Utrecht combines clinical and genetic data with cardiac tissue collected by the departments of pathology and cardiology from UMC Utrecht starting from the 1980’s. Included biobank materials are cardiac tissue (e.g. biopsies, heart slices), fibroblast cell cultures, plasma, and DNA. In total, more than 500 patients with an ischemic or non-ischemic cardiomyopathy who underwent a heart transplantation or left ventricular assist device implantation are included in the Cardiac Tissue Biobank Utrecht. This study catalogue is financially supported by BBMRI-NL, a Research Infrastructure financed by the Dutch government (NWO 184.021.007)

click here for Cardiac Tissue Biobank Utrecht

 International DCM database:

click here for the International DCM database